Variable and tissue-specific hormone resistance in heterotrimeric Gs protein -subunit (Gs ) knockout mice is due to tissue-specific imprinting of the Gs gene

Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling

Hundreds of hormones and ligands stimulate cyclic AMP (cAMP) signaling in different tissues through the activation of G-protein-coupled receptors (GPCRs). Although the functions and individual effectors of cAMP signaling are well characterized in many tissues, pleiotropic effects of GPCR agonists limit investigations of physiological functions of cAMP signaling in individual cell types at diffe...

, a Variant of Stimulatory G Protein - Subunit ( Gs ) , Is a Distinct , Membrane - Anchored GNAS Product that Can Mimic Gs

Endocrine Unit (C.A., M.J.M., H.A.W.T., M.B.), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; Department of Endodontics (C.A.), Center for Dental Sciences, Gülhane School of Medicine, 06018 Ankara, Turkey; Departments of Neurology (N.A., N.W.K., A.D.) and Pathology (N.W.K.), Boston University School of Medicine, Boston, Massachuse...

GS Shrestha

Genetic Analysis of the Drosophila Gs Gene

One of the best understood signal transduction pathways activated by receptors containing seven transmembrane domains involves activation of heterotrimeric G-protein complexes containing Gs , the subsequent stimulation of adenylyl cyclase, production of cAMP, activation of protein kinase A (PKA), and the phosphorylation of substrates that control a wide variety of cellular responses. Here, we r...

CIRC lesson_praise (GS)

Tonya ha s a b i g ma th t e s t t omor r ow and sh e n e ed s t o s t udy t on i gh t . W hi l e a t t h e g r o c e r y s t o r e s h e s e e s a Ginkgo B i l oba ad v e r t i s emen t t ha t c l a ims i t w i l l imp r o v e h e r memo r y. B e c au s e s h e wan t s t o d o w e l l o n h e r t e s t , s h e buy s t h e Ginkgo B i l oba , g o e s h ome , and r e v i ew s t h e s ame ma th sh...